Our pioneering investigations have brought us to a goldmine of protein modifications. Sirtuins, the protectors of our metabolism, hold a pivotal position. For example, SIRT3, a Sirtuin family member, acts as a maestro, coordinating the flawless harmony of fatty acid breakdown by controlling acetylation. However, this is only the tip of the iceberg - our work has uncovered a new ensemble of modifications such as glutarylation, HMG, MG, and 3MG. These groundbreaking insights unveil the countless ways proteins are modified to perform their duties.